POTSDAM -- The next Clarkson University Science Café will be Cyclic Dinucleotide Signaling in Mammalian Cells, Wednesday, March 13, 7:15 p.m. 

Cyclic dinucleotides have emerged as widely used signaling molecules in bacteria. 

The cyclic dinucleotides expressed in microbial organisms can be recognized by Stimulator of INterferon Genes (STING) of the innate immune system, and they trigger the inflammatory response. 

In 2013, researchers discovered human cGAS which could bind to cytosolic DNA and selectively catalyze the synthesis of cyclic dinucleotides.

This cGAS-STING pathway is important for the innate immune response, and targeting proteins along this pathway holds promise in the treatment of some specific diseases. Join us for an evening with Dr. Modi Wang (Chemistry & Biomolecular Science, CU) and to a discussion of her recent projects developing cGAS inhibitors and discovering new cyclic dinucleotides mediated pathways. 

The informal talks about science and research topics with a local researcher or expert will be held in the community Room at the Potsdam Civic Center, 2 Park St. 

Info: https://www.clarkson.edu/science-cafe, sciencecafe@clarkson.edu .